Florfenicolimhando ye monofluoro derivative ye thiamphenicol, fomura yemamorekuru iyi ndeye C12H14Cl2FNO4S, upfu hwe crystalline chena kana kuti husina kuchena, husina hwema, hunonyunguduka zvishoma mumvura uye chloroform, hunonyunguduka zvishoma mu glacial acetic acid, hunonyunguduka muMethanol, ethanol. Imishonga mitsva ye chloramphenicol inoshandiswa nemhuka, yakagadzirwa zvinobudirira mukupera kwema1980.
Yakatanga kutengeswa muJapan muna 1990. Muna 1993, Norway yakabvumidza mushonga wekurapa furuncle yesalmon. Muna 1995, France, United Kingdom, Austria, Mexico neSpain dzakabvumidza mushonga uyu wekurapa zvirwere zvekufema zvemombe. Wakatenderwawo kushandiswa sechikafu chenguruve muJapan neMexico kudzivirira nekurapa zvirwere zvebhakitiriya munguruve, uye China ikozvino yabvumidza mushonga uyu.
Mushonga unorwisa mabhakitiriya, unogadzira mhedzisiro yebhakitiriya yakafara nekudzivisa kushanda kwepeptidyltransferase, uye une hutachiona hwakafara hwebhakitiriya, kusanganisira dzakasiyana-siyanaGram-positiveuye mabhakitiriya asina kunaka uye mycoplasma. Mabhakitiriya ane hunhu hwakanyanya anosanganisira mombe nenguruve Haemophilus,Shigella dysenteriae, Salmonella, Escherichia coli, Pneumococcus, Influenza bacillus, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, nezvimwewo. Chigadzirwa ichi chinogona kupararira mumasero ebhakitiriya kuburikidza nekunyungudika kwemafuta, chinonyanya kushanda pachikamu chidiki che50s cheribosome yemabhakitiriya ema70s, chinodzivisa transpeptidase, chinodzivisa kukura kwepeptidase, chinodzivisa kuumbwa kwemaketani epeptide, nokudaro chinodzivirira kugadzirwa kweprotein, zvichizadzisa chinangwa cheAntibacterial. Chigadzirwa ichi chinokurumidza kutorwa nemuromo, chinopararira zvakanyanya, chine hafu yehupenyu, huwandu hwakawanda hwemishonga muropa, uye nguva refu yekuchengetedza mishonga muropa.
Mumakore achangopfuura, mapurazi mazhinji madiki nepakati enguruve akashandisa florfenicol kurapa zvisinei nemamiriro enguruve, uye akashandisa florfenicol semushonga wemashiripiti. Kutaura zvazviri, izvi zvine njodzi huru. Ine mhedzisiro yakanaka yekurapa zvirwere zvenguruve zvinokonzerwa nemabhakitiriya eGram-positive neasina kunaka uye mycoplasma, kunyanya mushure mekusanganiswa kweflorfenicol nedoxycycline, mhedzisiro yacho inowedzera, uye inoshanda mukurapa nguruve yechipfuva inokonzera rhinitis. Cocci, nezvimwewo, ine mhedzisiro yakanaka yekurapa.
Zvisinei, chikonzero nei zvichiva nengozi kushandisa florfenicol nguva dzose ndechekuti kune migumisiro yakawanda ye florfenicol, uye kushandisa florfenicol kwenguva refu kunokuvadza kupfuura kubatsira. Semuenzaniso, shamwari dzenguruve hadzifanirwe kufuratira pfungwa idzi.
1. Kana paine zvirwere zvemavhairasi zvakaita se pseudorabies swine fever ine blue ear ring mupurazi renguruve, kushandiswa kwe florfenicol pakurapa kunowanzova chikamu chezvirwere izvi zvemavhairasi, saka kana zvirwere zvataurwa pamusoro apa zvikabatwa nezvimwe zvirwere zvenguruve, usashandise florfenicol pakurapa, zvinozowedzera chirwere chacho.
2. Florfenicol inokanganisa hurongwa hwedu hweropa uye inodzivirira kugadzirwa kwemasero matsvuku eropa mumongo wemapfupa, kunyanya kana nguruve dzedu dzichiyamwa dzine dzihwa kana kuti majoini akazvimba. Ruvara rwebvudzi renguruve harusi runako, bvudzi rakakangwa, asi rinoratidzawo zviratidzo zvekushaya ropa, richaitawo kuti nguruve isadye kwenguva yakareba, zvichiita kuti nguruve iome.
3. Florfenicol ine chepfu mumwana asati aberekwa. Kana florfenicol ikashandiswa kakawanda panguva yekuzvitakura munguruve dzehadzi, nguruve dzinobva dzabuda hadzi dzinotadza kushanda.
4. Kushandisa florfenicol kwenguva refu kunokonzera matambudziko emudumbu uye manyoka munguruve.
5. Zviri nyore kukonzera hutachiona hwechipiri, senge exudative dermatitis inokonzerwa nehutachiona hwe staphylococcus munguruve kana hutachiona hwechipiri hweimwe fungus dermatitis.
Muchidimbu, florfenicol haifanirwe kushandiswa semushonga wemazuva ese. Kana tikashandisa mimwe mishonga inorwisa mabhakitiriya isina simba uye iri musanganiswa (expel virus), tinogona kushandisa florfenicol nedoxycycline. Acupuncture inoshandiswa kurapa zvirwere zvisingarapiki, uye haikurudzirwi kune dzimwe mamiriro ezvinhu.
Nguva yekutumira: Chikunguru-14-2022