Kuratidzwa kune pyrethroids kunogona kuwedzera njodzi yechirwere cheParkinson nekuda kwekudyidzana nemajini kuburikidza nemasoja emuviri.
Pyrethroids inowanikwa mune dzakawanda zvekutengeseranamishonga yemumba.Kunyangwe iwo ari neurotoxic kune zvipembenene, iwo anowanzoonekwa akachengeteka kuti abatane nevanhu nevakuru vemubatanidzwa.
Kusiyana kwemajini uye kuratidzwa kwemishonga yezvipembenene zvinoita sekupesvedzera njodzi yechirwere cheParkinson.Chidzidzo chitsva chinowana chinongedzo pakati pezvinhu zviviri izvi zvine njodzi, zvichiratidza basa remhinduro yekudzivirirwa kwezvirwere mukukura kwechirwere.
Zvakawanikwa zvine chekuita nekirasi yemishonga yezvipembeneneanonzi pyrethroids, anowanikwa mumishonga yakawanda yezvipembenene yemumba uye ari kunyanya kushandiswa mukurima sezvo mamwe mishonga yezvipembenene inobviswa.Kunyangwe pyrethroids iri neurotoxic kune zvipembenene, zviremera zvemubatanidzwa zvinowanzozviona zvakachengeteka kuratidzwa kwevanhu.
Chidzidzo ichi ndicho chekutanga kubatanidza kuratidzwa kwepyrethroid kungozi yemajini yechirwere cheParkinson uye inobvumidza zvidzidzo zvekutevera, akadaro munyori mukuru-mukuru Malu Tansi, Ph.D., mutevedzeri wepurofesa wefiziology paEmory University School of Medicine.
Iyo genetic musiyano iyo timu yakawana iri munharaunda isiri-coding yeMHC II (major histocompatibility complex class II) genes, boka remajini rinogadzirisa immune system.
"Tanga tisingatarisiri kuwana chinongedzo kune pyrethroids," Tansey akadaro.“Zvinozivikanwa kuti kubatwa zvakanyanya nepyrethroids kunogona kukonzera kusashanda kwezvirwere zvemuviri, uye mamorekuru aanoshanda paari anogona kuwanikwa mumasero anodzivirira zvirwere;Iye zvino tinoda kunzwisisa zvakawanda nezvekuti kuratidzwa kwenguva refu kunokanganisa sei immune system uye nekudaro inowedzera basa rayo. ”Ngozi yechirwere cheKinson. "
“Pane humbowo hwakasimba hunoratidza kuti kuzvimba kweuropi kana kuti kunyanyoshanda muviri kwomuviri kunodzivirira zvirwere kunogona kukonzera kukura kwechirwere cheParkinson."Isu tinofunga kuti zvingave zviri kuitika pano ndezvekuti kufumurwa kwezvakatipoteredza kunogona kuchinja maitiro ezvirwere mune vamwe vanhu, zvichikurudzira kuzvimba kusingaperi muuropi."
Pachidzidzo ichi, vatsvakurudzi veEmory vakatungamirirwa naTansey naJeremy Boss, Ph.D., sachigaro weDhipatimendi reMicrobiology uye Immunology, vakabatana naStuart Factor, Ph.D., mutungamiriri weEmory's Comprehensive Parkinson's Disease Center, naBeate Ritz., MD, Yunivhesiti yeCalifornia, San Francisco.Mukubatana nevatsvakurudzi vehutano hweveruzhinji paUCLA, Ph.D.Munyori wekutanga wechinyorwa ndiGeorge T. Kannarkat, MD.
Vatsvagiri veUCLA vakashandisa dhatabhesi reCalifornia geographic rinofukidza makore makumi matatu ekushandiswa kwemishonga yezvipembenene mukurima.Vakasarudza kuratidzwa zvichibva pachinhambwe (chebasa remumwe munhu nekero dzekumba) asi havana kuyera mazinga emishonga yezvipembenene mumuviri.Pyrethroids inofungidzirwa kuti inodzikisira nekukurumidza, kunyanya kana yakavhenekerwa nechiedza chezuva, nehafu yehupenyu muvhu remazuva kusvika kumavhiki.
Pakati pezvidzidzo zve962 kubva kuCalifornia's Central Valley, yakajairwa MHC II musiyano wakasanganiswa nepamusoro-avhareji kuratidzwa kumishonga yepyrethroid yakawedzera njodzi yechirwere cheParkinson.Nzira ine ngozi zvikuru yejini (vanhu vakatakura maalleles maviri engozi) yakawanikwa mu21% yevarwere vane chirwere cheParkinson uye 16% yezvidzoro.
Muboka iri, kuratidzwa kune gene kana pyrethroid chete hakuna kuwedzera zvakanyanya njodzi yechirwere cheParkinson, asi musanganiswa wakadaro.Zvichienzaniswa neavhareji, vanhu vakasangana nepyrethroids uye vakatakura fomu yepamusoro yengozi yeMHC II gene vaiva ne2.48 nguva yakakura yekuwana chirwere cheParkinson pane avo vane zvishoma zvishoma uye vakatakura fomu yengozi yakaderera yejini.ngozi.Kuratidzira kune mamwe marudzi emishonga yezvipembenene, senge organophosphates kana paraquat, haiwedzere njodzi nenzira imwecheteyo.
Zvidzidzo zvakakura zvemajini, kusanganisira Factor nevarwere vake, zvakambobatanidza MHC II gene kusiyana nechirwere cheParkinson.Zvinotoshamisa ndezvokuti kusiyana kwakafanana kwemajini kunokanganisa njodzi yechirwere cheParkinson zvakasiyana muCaucasians/Europeans and Chinese people.MHC II majini anosiyana zvakanyanya pakati pevanhu;saka, vanoita basa rinokosha pakusarudzwa kwenhengo dzomuviri.
Zvimwe zviedzo zvakaratidza kuti kusiyana kwemajini kwakabatana nechirwere cheParkinson kune hukama nekushanda kwesero rekudzivirira.Vatsvakurudzi vakaona kuti pakati pevarwere ve81 Parkinson's disease uye European controls kubva kuEmory University, masero ekudzivirira kubva kune vanhu vane ngozi yeMHC II yakasiyana-siyana kubva kuCalifornia kudzidza yakaratidza mamwe mamorekuru eMHC.
MHC mamorekuru ari pasi pemaitiro e "antigen presentation" uye ndiwo simba rinotyaira rinoita kuti T masero uye abatanidze mamwe immune system.MHC II kutaura kunowedzerwa mumasero akanyarara evarwere veParkinson's disease uye kutonga kwakanaka, asi mhinduro huru kune dambudziko rekudzivirira zvirwere rinoonekwa muvarwere veParkinson vane ngozi yepamusoro-genotypes;
Vanyori vakapedzisa: "Dzimwe yedu inoratidza kuti ma cellular biomarkers, akadai seMHC II activation, anogona kubatsira zvakanyanya kupfuura mamorekuru anonyungudika muplasma uye cerebrospinal fluid yekuona vanhu vari panjodzi yechirwere kana kupinza varwere kuti vatore chikamu mukuyedzwa kwemishonga inodzivirira zvirwere.""Muedzo."
Chidzidzo ichi chakatsigirwa neNational Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), National Institute of Environmental Health Sciences (5P01ES016731), National Institute of General Medical Sciences (GM47310), iyo Sartain Foundation, uye Sartain Foundation. iyo Michael J. Foxpa Kingson Foundation yeKutsvaga Chirwere.
Nguva yekutumira: Jun-04-2024