Kusangana nezvirwere zvepyrethroids kunogona kuwedzera njodzi yekubatwa nechirwere cheParkinson nekuda kwekubatana nemajini kuburikidza nemasoja emuviri.
MaPyrethroids anowanikwa muzvitoro zvakawandamishonga yezvipembenene yemumbaKunyangwe zvazvo dziine chepfu kuzvipembenene, dzinowanzoonekwa sedzakachengeteka kuti dzisabatwe nevanhu nehurumende.
Kusiyana kwemajini uye kushandiswa kwemishonga inouraya zvipembenene kunoita sekunge ndiko kunokanganisa njodzi yechirwere cheParkinson. Ongororo itsva yakawana hukama pakati pezvinhu zviviri izvi zvine njodzi, ichiratidza basa remuviri wekudzivirira chirwere mukufambira mberi kwechirwere.
Zvakawanikwa zvine chekuita neboka remishonga yezvipembeneneinonzi pyrethroids, inowanikwa mumishonga yakawanda yemishonga yemumba uye iri kushandiswa zvakanyanya mukurima sezvo mimwe mishonga yekuuraya zvipembenene iri kubviswa. Kunyangwe mishonga yepyrethroids ichikuvadza zvipembenene nepfungwa, vakuru vakuru vehurumende vanowanzoiona seyakachengeteka kuti isaparadzwe nevanhu.
Chidzidzo ichi ndicho chekutanga chekubatanidza kusangana kwechirwere chepyrethroid nenjodzi yemajini inokonzera chirwere cheParkinson uye chinofanirwa kuteverwa nezvidzidzo, akadaro mumwe wevanyori vakuru Malu Tansi, Ph.D., mubatsiri wepurofesa wezvefiziyoloji paEmory University School of Medicine.
Mhando yemajini yakawanikwa nechikwata ichi iri munzvimbo isina kunyorwa kwemajini eMHC II (major histocompatibility complex class II), boka remajini anodzora masoja emuviri.
"Takanga tisingatarisiri kuwana hukama chaihwo ne pyrethroids," akadaro Tansey. "Zvinozivikanwa kuti kusangana ne pyrethroids nekukurumidza kunogona kukonzera kusagadzikana kwemasoja ekudzivirira muviri, uye mamorekuru aanoshanda nawo anogona kuwanikwa mumasero emasoja ekudzivirira muviri; Iye zvino tinofanira kunzwisisa zvakawanda nezvekuti kusangana kwenguva refu kunokanganisa sei masoja ekudzivirira muviri uye nokudaro kunowedzera mashandiro awo." Njodzi yechirwere cheKinson."
"Patova nehumbowo hwakasimba hwekuti kuzvimba kweuropi kana kuti immune system inoshanda zvakanyanya zvinogona kukonzera kupararira kwechirwere cheParkinson. "Tinofunga kuti chingave chiri kuitika pano ndechekuti kusangana nezvakatipoteredza kunogona kuchinja maitiro ekudzivirira muviri mune vamwe vanhu, zvichikonzera kuzvimba kwenguva refu muuropi."
Pachidzidzo ichi, vaongorori veEmory vachitungamirwa naTansey naJeremy Boss, Ph.D., sachigaro weDhipatimendi reMicrobiology neImmunology, vakabatana naStuart Factor, Ph.D., director weEmory's Comprehensive Parkinson's Disease Center, naBeate Ritz., MD, University of California, San Francisco. Vachishanda pamwe chete nevaongorori vehutano hweveruzhinji kuUCLA, Ph.D. Munyori wekutanga wechinyorwa ichi ndiGeorge T. Kannarkat, MD.
Vaongorori veUCLA vakashandisa database yenzvimbo yeCalifornia vachiongorora makore makumi matatu ekushandiswa kwemishonga inouraya zvipembenene mukurima. Vakaona kuti mishonga inouraya zvipembenene inosangana nezvipembenene izvi zvichienderana nedaro (basa remumwe munhu nekero dzepamba) asi havana kuyera huwandu hwemishonga inouraya zvipembenene mumuviri. Mishonga inouraya zvipembenene inonzi pyrethroids inokurumidza kuora, kunyanya kana ikasangana nezuva, nehafu yehupenyu muvhu hwemazuva kusvika mavhiki.
Pakati pevanhu 962 vakaongororwa kubva kuCentral Valley yeCalifornia, mhando yeMHC II yakajairika pamwe chete nekusangana nemishonga inouraya zvipembenene inonzi pyrethroid yakawedzera njodzi yechirwere cheParkinson. Rudzi rwejini rune njodzi huru (vanhu vane alleles mbiri dzinokonzera njodzi) rwakawanikwa mu21% yevarwere vane chirwere cheParkinson uye 16% yevarwere vane chirwere ichi.
Muboka iri, kusangana nejini kana pyrethroid chete hakuna kuwedzera zvakanyanya njodzi yechirwere cheParkinson, asi musanganiswa wacho wakawedzera zvakanyanya. Zvichienzaniswa neavhareji, vanhu vakasangana nepyrethroid uye vaive nerudzi rweMHC II gene rine njodzi huru vaive ne2.48 nguva yakawanda yekuva nechirwere cheParkinson kupfuura avo vasina kubatwa zvakanyanya uye vaive nerudzi rwenjodzi yakaderera yejini. Kusangana nemamwe marudzi emishonga inouraya zvipembenene, senge organophosphates kana paraquat, hakuwedzeri njodzi nenzira imwecheteyo.
Zvidzidzo zvikuru zvemajini, kusanganisira Factor nevarwere vake, zvakambobatanidza kusiyana kwemajini eMHC II nechirwere cheParkinson. Zvinoshamisa kuti kusiyana kwemajini kumwe chete uku kunokanganisa njodzi yechirwere cheParkinson zvakasiyana muvanhu vekuCaucasian/Europe nevanhu vekuChina. Majini eMHC II akasiyana zvikuru pakati pevanhu; saka, anoita basa rakakosha mukusarudza kwevanoisirwa nhengo.
Zvimwe zvakaongororwa zvakaratidza kuti kusiyana kwemajini kunobatanidzwa nechirwere cheParkinson kwakabatana nekushanda kwemasero ekudzivirira muviri. Vaongorori vakaona kuti pakati pevarwere 81 vane chirwere cheParkinson pamwe nevanoona nezvehutachiona vekuEurope vanobva kuEmory University, masero ekudzivirira muviri kubva kuvanhu vane mhando dzemajini eMHC II ane njodzi huru kubva kuongororo yeCalifornia yakaratidza mamorekuru akawanda eMHC.
Mamorekuru eMHC ndiwo anotungamira maitiro e "antigen presentation" uye ndiwo simba rinoita kuti masero eT ashande uye anobata mamwe masoja ekudzivirira muviri. Kuonekwa kweMHC II kunowedzera mumasero akanyarara evarwere vane chirwere cheParkinson uye vanodzora vane hutano, asi mhinduro yakakura kumatambudziko ekudzivirira muviri inoonekwa muvarwere vane chirwere cheParkinson vane majini ane njodzi huru;
Vanyori vakagumisa vachiti: “Data redu rinoratidza kuti ma biomarker emasero, akadai seMHC II activation, anogona kubatsira kupfuura mamorekuru anonyungudika muplasma uye cerebrospinal fluid pakuziva vanhu vari panjodzi yekurwara kana kuti pakutsvaga varwere kuti vatore chikamu mukuyedzwa kwemishonga yekudzivirira muviri.” ”Bvunzo.”
Chidzidzo ichi chakatsigirwa neNational Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), National Institute of Environmental Health Sciences (5P01ES016731), National Institute of General Medical Sciences (GM47310), Sartain Lanier Family Foundation, uye Michael J. Foxpa Kingson Foundation for Disease Research.
Nguva yekutumira: Chikumi-04-2024