Vatsvagiri kubva kuDhipatimendi reBiochemistry kuIndia Institute of Sayenzi (IISc) vakawana nzira yakatsvakwa kwenguva refuyekudzora kukura kwezvirimwa zvepasi zvekare senge bryophytes (boka rinosanganisira mosses uye liverworts) iro rakachengetwa mumiti inotumbuka gare gare.
Chidzidzo ichi, chakaburitswa mujenari Nature Chemical Biology, yakanangana neiyo isiri-canonical regulation yeDELLA mapuroteni, inyanzvi yekukura inodzvanya kupatsanurwa kwesero mu embryophytes (zvidyarwa zvevhu).
Sezvineiwo, bryophytes, zvirimwa zvekutanga kuoneka panyika makore angangoita 500 miriyoni apfuura, inoshaya GID1 receptor, kunyangwe ichigadzira iyo phytohormone GA. Izvi zvinomutsa mubvunzo wekuti kukura nekusimudzirwa kwezvidyarwa zvevhu zvekutanga zvakadzorwa sei.
Vachishandisa liverwort Marchantia polymorpha semuenzanisi sisitimu, vaongorori vakawana kuti izvi zvidyarwa zvekare zvinoshandisa yakasarudzika enzyme, MpVIH, iyo inoburitsa cellular messenger inositol pyrophosphate (InsP₈), kuputsa DELLA pasina kubatanidzwa kwegibberellic acid.
Vatsvagiri vakashandisa iyo CRISPR-Cas9 sisitimu kugogodza iyo gene encoding iyo VIH enzyme, ichisimbisa basa rayo. Zvirimwa zvisingashande VIH zvakaratidza hurema hwakanyanya hwekukura uye morphological abnormalities, senge mashizha compact, kukanganiswa kweradial kukura, uye kushaikwa kwemakasi. Izvi zvakakanganisika zvakabviswa nekugadzirisa genome yechirimwa kuti ibudise mugumo mumwe chete (iyo N-terminus) yeVIH enzyme. Ichishandisa advanced chromatography matekiniki, timu yakaona kuti N-terminus ine kinase domain inokonzeresa kugadzirwa kweInsP₈.
Vatsvagiri vakawana kuti DELLA ndeimwe yemaserura anotariswa eVIH kinase. Uyezve, vakacherechedza kuti phenotypes yemiti yeMpVIH-yakashaya yakanga yakafanana neyeM. polymorpha miti ine kuwedzera DELLA kutaura.
"Panguva ino, takafara kunzwisisa kana kugadzikana kana chiitiko cheDELLA chichisimudzirwa mumiti isina kukwana yeMpVIH," akadaro Priyanshi Rana, munyori wekutanga uye mudzidzi akapedza kudzidza muboka rekutsvaga raLahey. Zvichienderana nefungidziro yavo, vaongorori vakawana kuti DELLA inhibition inogona zvakanyanya kudzoreredza kukura kwakashata uye budiriro phenotypes yeMpVIH mutant zvirimwa. Mhedzisiro iyi inoratidza kuti VIH kinase inodzora DELLA zvisina kunaka, ichikurudzira kukura nekukura kwechirimwa.
Tsvagiridzo mumapuroteni eDELLA yakatanga kuGreen Revolution, apo masayendisiti nekusaziva vakashandisa mukana wavo kugadzira mhando dzinopa goho rehafu-diki. Kunyangwe ruzivo rwebasa ravo rwakanga rusina kujeka panguva iyoyo, tekinoroji yemazuva ano inobvumira masayendisiti kushandura mashandiro emapuroteni aya kuburikidza neinjiniya yemajini, zvichiwedzera kuwedzera goho rezvirimwa.
Nguva yekutumira: Oct-23-2025