Vatsvakurudzi vakaona kuti zvirimwa zvinodzora sei mapuroteni eDELLA.

Vatsvaguriri vanobva kuDhipatimendi reBiochemistry kuIndian Institute of Sciences (IISc) vakawana nzira yagara ichitsvagwayekutonga kukura kwezvirimwa zvekare zvepanyika zvakaita sebryophytes (boka rinosanganisira mosses neliverworts) izvo zvakachengetwa muzvirimwa zvakazobuda maruva gare gare.
Chidzidzo ichi, chakaburitswa mumagazini inonzi Nature Chemical Biology, chakanyanya kutarisa pakudzora mapuroteni eDELLA zvisiri zvemutemo, murairidzi mukuru wekukura uyo unoderedza kupatsanurwa kwemasero mu embryophytes (zvirimwa zvemuvhu).
Zvinofadza kuti, bryophytes, zvirimwa zvekutanga kuonekwa panyika makore angangoita mamiriyoni mazana mashanu apfuura, hazvina GID1 receptor, kunyangwe zvichigadzira phytohormone GA. Izvi zvinomutsa mubvunzo wekuti kukura nekukura kwezvirimwa izvi zvepakutanga zvaidzorwa sei.
Vachishandisa liverwort Marchantia polymorpha senzira yekuenzanisira, vaongorori vakaona kuti zvirimwa izvi zvekare zvinoshandisa enzyme yakasarudzika, MpVIH, iyo inogadzira cellular messenger inositol pyrophosphate (InsP₈), kuputsa DELLA pasina kubatanidzwa kwegibberellic acid.
Vaongorori vakashandisa CRISPR-Cas9 system kubvisa jini rinoisa enzyme yeVIH, zvichiratidza basa rayo. Zvirimwa zvisina VIH inoshanda zvakaratidza zvikanganiso zvakakomba pakukura uye kusarongeka kwechimiro, zvakaita semashizha akamanikana, kukura kweradial kusina kunaka, uye kushaya macalyxes. Kukanganisika uku kwakabviswa nekushandura genome yemiti kuti igadzire mugumo mumwe chete (N-terminus) weenzyme yeVIH. Vachishandisa nzira dzepamusoro dzechromatography, timu iyi yakawana kuti N-terminus ine kinase domain inokonzeresa kugadzirwa kweInsP₈.
Vaongorori vakaona kuti DELLA ndeimwe yezvinangwa zveVIH kinase mumasero. Uyezve, vakaona kuti maitiro emiti isina MpVIH akafanana neemiti yeM. polymorpha ine kuwedzera kwekutaura kweDELLA.
"Panguva ino, takafara kunzwisisa kana kugadzikana kana kushanda kweDELLA kuchiwedzerwa muzvirimwa zvisina MpVIH," akadaro Priyanshi Rana, munyori wekutanga uye mudzidzi wepashure pekudzidza muboka rekutsvagisa raLahey. Zvichienderana nefungidziro yavo, vaongorori vakawana kuti kudziviswa kweDELLA kunogona kudzorera zvakanyanya kukura kwakakanganisika uye kukura kwezvirimwa zvakachinja zveMpVIH. Mhedzisiro iyi inoratidza kuti VIH kinase inodzora DELLA zvisina kunaka, ichikurudzira kukura nekukura kwezvirimwa.
Tsvakurudzo pamusoro pemapuroteni eDELLA yakatangira kuGreen Revolution, apo masayendisiti akashandisa simba ravo vasingazive kugadzira mhando dzemhando ...