Dzidzisai kushandisa florfenicol, zvinoshamisa kurapa chirwere chenguruve!

Florfenicolmushonga unorwisa mabhakitiriya une spectrum yakakura, une simba rakanaka rekudzivirira mabhakitiriya ane Gram-positive uye mabhakitiriya asina kunaka. Nokudaro, mapurazi mazhinji enguruve anowanzo shandisa florfenicol kudzivirira kana kurapa nguruve kana dziine zvirwere zvakawanda. Vashandi vezvipfuyo vemamwe mapurazi enguruve vanoshandisa florfenicol yakawanda kurapa kana kudzivirira zvirwere zvisinei nechirwere, zvisinei neboka kana danho. Florfenicol haisi mushonga wekurapa, uye inofanira kushandiswa zvine musoro kuti iwane mhedzisiro inodiwa. Pasi apa tinopa pfungwa yakajairika yekushandiswa kweflorfenicol zvakadzama, tichitarisira kubatsira varimi vazhinji venguruve:

1. Hunhu hwemabhakitiriya eflorfenikol

1. Ine huwandu hwakakura hwemabhakitiriya anorwisa mabhakitiriya, uye ine simba guru rekuuraya mabhakitiriya ane Gram-positive nemabhakitiriya asina kunaka, pamwe nemabhakitiriya ane Gram-positive nemabhakitiriya asina kunaka eGram-positive nemaspirochetes, rickettsia, amoeba, nezvimwewo. Simba guru remabhakitiriya anorwisa mabhakitiriya.

2. Kuedza kwemushonga wekudzivirira utachiona mumuviri (in vitro) uye mumuviri (in vivo) kunoratidza kuti kushanda kwayo kwemishonga inorwisa mabhakitiriya kuri nani zvikuru kupfuura mishonga inorwisa mabhakitiriya iripo pari zvino.

3. Florfenicol inoshanda nekukurumidza, inogona kusvika pahuwandu hwekurapa muropa awa imwe chete mushure mekubaiwa jekiseni remutsinga, uye huwandu hwepamusoro hwemushonga hunogona kusvika mumaawa 1.5-3; huwandu hwemushonga muropa hunoshanda kwenguva refu uye hunoshanda hunogona kuramba huripo kwemaawa anopfuura makumi maviri mushure mekushandisa kamwe chete.

4. Inogona kupinda muropa-uropi, uye mhedzisiro yayo yekurapa meningitis yemabhakitiriya emhuka haienzaniswi nemimwe mishonga inorwisa mabhakitiriya.

5. Haina chepfu kana migumisiro yakaipa kana ikashandiswa muhuwandu hunokurudzirwa, inokunda njodzi yeaplastic anemia uye humwe huturu hunokonzerwa nethiamphenicol, uye haikuvadzi mhuka nechikafu. Inoshandiswa pakutapukirwa kwezvikamu zvakasiyana-siyana zvemuviri zvinokonzerwa nemabhakitiriya mumhuka. Kurapa, kunosanganisira kudzivirira nekurapa zvirwere zvekufema zvebhakitiriya, meningitis, pleurisy, mastitis, hutachiona hwemudumbu uye postpartum syndrome munguruve.

2. Mabhakitiriya anobatwa nechirwere ichiflorfenikol

1. Zvirwere zvenguruve uko florfenicol inonyanya kufarirwa

Mushonga uyu unokurudzirwa semushonga unonyanya kusarudzwa we pneumonia yenguruve, porcine infectious pleuropneumonia uye chirwere cheHaemophilus parasuis, kunyanya pakurapa mabhakitiriya asingade fluoroquinolones nemamwe ma antibiotic.

2. Florfenicol inogona kushandiswawo pakurapa zvirwere zvenguruve zvinotevera

Inogona zvakare kushandiswa kurapa zvirwere zvekufema zvinokonzerwa neStreptococcus (pneumonia), Bordetella bronchiseptica (atrophic rhinitis), Mycoplasma pneumoniae (swine asthma), nezvimwewo; salmonellosis (piglet paratyphoid), colibacillosis (piglet asthma) Zvirwere zvemudumbu zvakaita se enteritis inokonzerwa ne yellow diarrhea, chena diarrhea, piglet edema disease) nezvimwe zvirwere zvinotapukira. Florfenicol inogona kushandiswa kurapa zvirwere izvi zvenguruve, asi haisi mushonga unoshandiswa pakurapa zvirwere izvi zvenguruve, saka inofanira kushandiswa nekungwarira.

3. Kushandiswa zvisina kunaka kweflorfenikol

1. Dose yacho yakakura zvakanyanya kana kuti diki. Dose huru dzine chepfu, uye dose diki hadzishande..

2. Nguva yacho yakareba zvakanyanya. Kushandisa mishonga kwenguva refu pasina kurambidzwa.

3.kushandiswa kwezvinhu, zvikanganiso zvedanho. Nguruve dzehadzi dzine pamuviri nenguruve dzinokora dzinoshandisa mishonga yakadaro zvisina tsarukano, zvichikonzera chepfu kana masara emishonga, zvichikonzera kugadzirwa kwemhuka nechikafu chisina kuchengetedzeka.

4. Kusashanda zvakanaka kwemishonga iyi. Vamwe vanhu vanowanzo shandisa florfenicol pamwe chete ne sulfonamides ne cephalosporins. Zvakakosha kuongorora kana iri yesainzi uye ine musoro.

5. Kudya kwakasanganiswa hakusanganiswi zvakaenzana, zvichiita kuti pasave nemigumisiro yemushonga kana chepfu yemushonga.

Chechina, kushandiswa kweflorfenikolzvekungwaririra

1. Mushonga uyu haufanirwe kushandiswa pamwe chete nema macrolides, lincosamides uye diterpenoid semi-synthetic antibiotics - Tiamulin, iyo inogona kukonzera mhedzisiro inopikisa kana ikashandiswa pamwe chete..

2. Chigadzirwa ichi hachigone kushandiswa pamwe chete neβ-lactone amines uye fluoroquinolones, nekuti chigadzirwa ichi chinhu chinokurumidza kushanda nemabhakitiriya chinodzivirira kugadzirwa kwemapuroteni emabhakitiriya, uye chekupedzisira chinouraya mabhakitiriya chinokurumidza kushanda panguva yekubereka. Pasi pekushanda kwechekutanga, kugadzirwa kwemapuroteni emabhakitiriya kunodziviswa nekukurumidza, mabhakitiriya anomira kukura nekuwanda, uye simba rekuuraya mabhakitiriya rechekupedzisira rinodzikira. Saka, kana kurapwa kuchida kukurumidza kuita sterilization effect, hakugone kushandiswa pamwe chete.

3. Mushonga uyu haugone kusanganiswa nesulfadiazine sodium kuti upinzwe mutsinga. Haufanirwe kushandiswa pamwe chete nemishonga yealkaline kana uchipiwa nemuromo kana netsinga, kuitira kudzivirira kuora nekukundikana. Hauna kukodzerawo kubaiwa netsinga ne tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, nezvimwewo, kudzivirira kunaya kwemvura uye kudzikira kwekushanda kwayo.

4. Kuora kwetsandanyama uye kupararira kwemasero etsinga zvinogona kukonzerwa mushure mekubayiwa jekiseni remutsinga. Saka, rinogona kubaiwa netsandanyama dzakadzika dzemutsipa nemagaro, uye hazvikurudzirwi kudzokorora kubaiwa jekiseni panzvimbo imwe chete.

5. Sezvo mushonga uyu uchigona kuva nehuturu mudumbu, unofanira kushandiswa nokungwarira kunguruve dzine mimba nedzinoyamwisa.

6. Kana tembiricha yemuviri yenguruve dzinorwara yakakwira, inogona kushandiswa pamwe chete nemishonga inorwisa marwadzo inorwisa marwadzo uye dexamethasone, uye mhedzisiro yacho inova nani..

7. Mukudzivirira nekurapa chirwere chekufema chenguruve (PRDC), vamwe vanhu vanokurudzira musanganiswa we florfenicol ne amoxicillin, florfenicol ne tylosin, uye florfenicol ne tylosin, izvo zvisina kukodzera. , nekuti kubva pamaonero emishonga, zviviri izvi hazvigone kushandiswa pamwe chete. Zvisinei, florfenicol inogona kushandiswa pamwe chete ne tetracyclines dzakadai se doxycycline..

8. Mushonga uyu une chepfu muropa. Kunyangwe usingazokonzere anemia yemapfupa asina kudzoreka, kudziviswa kwe erythropoiesis kunokonzerwa nawo kwakajairika kupfuura chloramphenicol (yakaremara). Hazvibvumirwi panguva yekubaiwa nhomba kana mhuka dzine immune deficiency yakanyanya..

9. Kushandiswa kwenguva refu kunogona kukonzera matambudziko ekugaya chikafu uye kushomeka kwemavhitamini kana zviratidzo zve superinfection..

10. Mukudzivirira nekurapa zvirwere zvenguruve, kungwarira kunofanira kuitwa, uye mushonga wacho unofanira kupiwa zvichienderana nechiyero chakatarwa uye nzira yekurapa, uye haufanirwe kushandiswa zvisina kunaka kudzivirira migumisiro yakaipa..

11. Kumhuka dzine dambudziko reitsvo, mushonga unofanira kuderedzwa kana kuti nguva yekushandiswa inofanira kuwedzerwa..

12. Kana tembiricha yakaderera, zvinoonekwa kuti mwero wekunyungudika unononoka; kana kuti mushonga wakagadzirwa une florfenicol, kungoti kupisa zvishoma (kwete kupfuura 45 degrees Celsius).℃), zvese zvinogona kunyungudutswa nekukurumidza. Mushonga wakagadzirwa unofanirwa kushandiswa mukati memaawa makumi mana nemasere..

Zvakachengeteka kushandisa fomu yakakodzera yemushonga zvichienderana nekutanga kwataurwa pamusoro apa uye tarisa mupimo unokurudzirwa. Mhuka imwe neimwe inogona kurasikirwa nechido kwenguva pfupi, kunwa mvura shoma kana manyoka, kurwadziwa kudiki panzvimbo yekubaiwa jekiseni mutsinga uye kuita zvishoma kwenyama, izvo zvese zvakajairika uye zvinodzokera kune zvakajairika mushure mekumira mushonga.