Dzidzisa iwe kushandisa florfenicol, zvinoshamisa kurapa chirwere chenguruve!

Florfenicolmushonga unorwisa mabhakitiriya wakafara, une simba rekudzivirira paGram-positive bacteria uye utachiona husina kunaka.Nokudaro, mapurazi akawanda enguruve anowanzo shandisa florfenicol kudzivirira kana kubata nguruve munyaya yezvirwere zvinowanzoitika.kurwara.Vashandi vezvipfuyo vemamwe mapurazi enguruve vanoshandisa super-dose yeflorfenicol kurapa kana kudzivirira zvirwere zvisinei nechirwere, zvisinei neboka kana danho.Florfenicol haisi panacea, uye inoda kushandiswa zvine musoro kuti iwane mhedzisiro yaunoda.Pazasi tinosuma pfungwa yakajairika yekushandiswa kweflorfenicol zvakadzama, tichitarisira kubatsira kune vazhinji vevarimi venguruve:

1. Antibacterial properties yeflorfenicol

1. Iine yakakura kwazvo antibacterial spectrum, uye ine simba rakasimba rekuuraya paGram-positive mabhakitiriya uye mabhakitiriya asina kunaka, pamwe neanaerobic Gram-positive bacteria uye spirochetes yakaipa, rickettsia, amoeba, etc. Strong antibacterial effect.

2. In vitro uye in vivo kuedza kunoratidza kuti basa rayo rinorwisa mabhakitiriya riri nani zvikuru kupfuura ikozvino mishonga inorwisa mabhakitiriya.

3. Kurumidza-kuita, florfenicol inogona kusvika kuhutano hwekurapa muropa 1 awa mushure mejojo ​​ye intramuscular, uye peak drug concentration inogona kusvika mumaawa 1.5-3;kushanda kwenguva refu, kushanda kwemishonga yeropa kunogona kuchengetwa kwemaawa anopfuura makumi maviri mushure mekutonga kumwe.

4. Inogona kupinda muropa-brain chipingamupinyi, uye maitiro ayo ekurapa pamhuka yebhakitiriya meningitis haienzaniswi nemamwe mishonga inorwisa mabhakitiriya.

5. Haina chepfu uye mhedzisiro kana yakashandiswa muhuwandu hunokurudzirwa, inokunda njodzi yeaplastic anemia uye humwe huturu hunokonzerwa nethiamphenicol, uye haikonzeri kukuvadza kumhuka uye chikafu.Inoshandiswa pahutachiona hwezvikamu zvakasiyana-siyana zvemuviri zvinokonzerwa nebhakitiriya mumhuka.Kurapa, kusanganisira kudzivirira uye kurapwa kwehutachiona hwekufema zvirwere, meningitis, pleurisy, mastitis, zvirwere zvemukati uye postpartum syndrome munguruve.

2. Mabhakitiriya anobatwa neflorfenicol

1. Zvirwere zvenguruve apo florfenicol inosarudzwa

Ichi chigadzirwa chinokurudzirwa semushonga wesarudzo yenguruve yemabayo, porcine infectious pleuropneumonia uye Haemophilus parasuis chirwere, kunyanya pakurapa utachiona hunopesana nefluoroquinolones nemamwe maantibioti.

2. Florfenicol inogonawo kushandiswa pakurapa zvirwere zvenguruve zvinotevera

Inogonawo kushandiswa kurapa zvirwere zvekufema zvinokonzerwa neStreptococcus (pneumonia), Bordetella bronchiseptica (atrophic rhinitis), Mycoplasma pneumoniae (swine asthma), nezvimwewo;salmonellosis (piglet paratyphoid), colibacillosis (piglet asthma) Zvirwere zvemudumbu zvakadai se enteritis zvinokonzerwa neyero manyoka, white diarrhea, piglet edema chirwere) uye mamwe mabhakitiriya anonzwa.Florfenicol inogona kushandiswa pakurapa zvirwere zvenguruve idzi, asi haisi mishonga yekusarudza kune zvirwere zvenguruve, saka inofanira kushandiswa nekuchenjerera.

3. Kusashandisa zvisina kunaka kweflorfenicol

1. Mushonga wacho wakakurisa kana kuti muduku.Mishonga mikuru ine chepfu, uye mishoma haishande..

2. nguva yakarebesa.Kumwe kushandiswa kwenguva refu kwemishonga yakawanda pasina kuzvidzora.

3.kushandiswa kwezvinhu, kukanganisa kwedariro.Mbeu dzine nguruve uye nguruve dzakakora dzinoshandisa mishonga yakadai zvisina tsarukano, zvichiita kuti muchetura kana zvisaririra zvemishonga, zvichikonzera kugadzirwa kusina kuchengetedzeka uye chikafu.

4. Kusawirirana kusina kunaka.Vamwe vanhu vanowanzoshandisa florfenicol pamwe chete ne sulfonamides uye cephalosporins.Kana zviri zvesainzi uye zvine musoro zvakakodzera kuongorora.

5. Kudyisa kwakasanganiswa hakusi kubvongodzwa, zvichiita kuti pasava nemigumisiro yemishonga kana chepfu yezvinodhaka.

Chechina, kushandiswa kweflorfenicolzvekungwaririra

1. Ichi chigadzirwa hachifaniri kushandiswa pamwe chete nemacrolides, lincosamides uye diterpenoid semi-synthetic antibiotics - Tiamulin, iyo inogona kubudisa migumisiro inopikisa kana yakashandiswa pamwe chete..

2. Ichi chigadzirwa hachigone kushandiswa pamwe chete neβ-lactone amines uye fluoroquinolones, nokuti chigadzirwa ichi chinokurumidza-chinoita bacteriostatic agent iyo inhibits bhakitiriya mapuroteni synthesis, uye iyo yekupedzisira ndeyekukurumidza-kuita bactericide munguva yekubereka.Pasi pechiito chekare, bhakitiriya mapuroteni synthesis anokurumidza kudziviswa, mabhakitiriya anomira kukura uye kuwedzera, uye bactericidal effect yekupedzisira inopera simba.Naizvozvo, kana kurapwa kuchida kuita nekukurumidza sterilization mhedzisiro, haigone kushandiswa pamwechete.

3. Ichi chigadzirwa hachigoni kusanganiswa ne sulfadiazine sodium yejekiseni ye intramuscular.Hazvifanirwe kushandiswa pamwe chete nemishonga yealkaline painobatwa nemuromo kana intramuscularly, kuitira kuti udzivise kuora uye kukundikana.Izvo zvakare hazvina kukodzera jekiseni remutsinga ne tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, nezvimwewo, kudzivirira kunaya uye kuderera mukubudirira.

4. Kuderera kwetsandanyama uye necrosis inogona kukonzerwa mushure mejojo ​​ye intramuscular.Nokudaro, inogona kubayiwa zvakasiyana mumhasuru dzakadzika dzemutsipa nemagaro, uye hazvikurudzirwe kudzokorora majekiseni panzvimbo imwechete.

5. Sezvo chigadzirwa ichi chingave chine embryotoxicity, chinofanira kushandiswa nekuchenjerera mumhuka dzine pamuviri uye dzinoyamwisa.

6. Kana kupisa kwemuviri wenguruve dzinorwara kwakakwirira, inogona kushandiswa ne antipyretic analgesics uye dexamethasone, uye mhedzisiro yacho iri nani..

7. Mukudzivirira uye kurapwa kweporcine breathing syndrome (PRDC), vamwe vanhu vanokurudzira kusanganiswa kweflorfenicol uye amoxicillin, florfenicol uye tylosin, uye florfenicol uye tylosin, iyo isina kufanira., nokuti kubva pane imwe nzvimbo yemishonga, iyo miviri haigoni kushandiswa pamwe chete.Nekudaro, florfenicol inogona kushandiswa pamwe chete ne tetracyclines senge doxycycline..

8. Ichi chigadzirwa chine hematological toxicity.Kunyange zvazvo isingazokonzeri mapfupa asingagadziriswi aplastic anemia, reversible erythropoiesis inhibition inokonzerwa nayo inowanzoitika kupfuura chloramphenicol (yakaremara).Inopesana munguva yekudzivirira kana mhuka dzine immunodeficiency yakaoma..

9. Kushandiswa kwenguva refu kunogona kukonzera kusagadzikana kwekudya uye kushayikwa kwevhitamini kana zviratidzo zve superinfection..

10. Mukudzivirira uye kurapwa kwezvirwere zvenguruve, kutarisirwa kunofanira kutorwa, uye mushonga unofanirwa kutungamirirwa maererano nechiyero chakatarwa uye nzira yekurapa, uye haifaniri kushandiswa zvisina kunaka kuti irege migumisiro yakaipa..

11. Kune mhuka dzine renal insufficiency, muyero unofanirwa kuderedzwa kana nguva yekutonga inofanira kuwedzerwa..

12. Muchiitiko chekushisa kwakadzika, kunowanikwa kuti kupera kwekugadzirisa kunononoka;kana mhinduro yakagadzirirwa ine kunaya kweflorfenicol, kungodziya kushoma (kwete kupfuura 45℃), ose anogona kukurumidza kunyungudutswa.Mushonga wakagadzirirwa unoshandiswa zvakanakisisa mukati memaawa makumi mana nemasere..

Zvakachengeteka kwazvo kushandisa fomu rakakodzera redosi zvinoenderana nenhanganyaya iri pamusoro uye tarisa kune yakakurudzirwa dosage.Mhuka imwe neimwe inogona kunzwa kurasikirwa kwechido kwenguva pfupi, kuderedzwa kwemvura kunwa kana manyoka, kurwadziwa kuduku panzvimbo yejekiseni re intramuscular uye zvishomanana maitiro, izvo zvose zvinowanzoitika uye zvinodzokera kune zvakajairika mushure mekumisa mushonga.