Mumiedzo muAfrica, mambure akagadzirwaPYRETHROIDuyeFIPRONILyakaratidza kuvandudza entomological uye epidemiological madhara.Izvi zvakonzera kuwedzera kudiwa kweiyi kosi nyowani yepamhepo munyika dzine malaria.PermaNet Dual itsva deltamethrin uye clofenac mesh yakagadziridzwa neVestergaard Sàrl kupa humwe hunyanzvi kuzvirongwa zvekudzivirira marariya.Takaita muyedzo wemutyairi wevatyairi kuona kushanda kwePermaNet Dual pakurwisa mosquito dzemusango, dzinobhururuka pyrethroid dzinoshingirira dzeAnopheles gambiae muCove, Benin.PermaNet Dual yakakonzera kufa kweumhutu kwakanyanya kana isina kugezwa zvichienzaniswa nemambure ane pyrethroid chete uye mambure ane pyrethroid nePIPERONYL BUTOXIDE (77% yePermaNet Dual, 23% yePermaNet 2.0 uye 23% yePermaNet 3.0) 56% 000 makore <20 makore mushure 0. .mawachi emhando (75% yePermaNet Dual, 14% yePermaNet 2.0, 30% yePermaNet 3.0, p <0.001).Kushandisa mapeji epakati asina kuderera anotsanangurwa neWorld Health Organization, PermaNet Dual yakanga isiriwo yakaderera mukutakura kufa kune pyrethroid-clofenazoline, iyo yakaratidza kuvandudzwa kwehutano hwehutano hwevanhu (Interceptor G2) (79% vs 76).%, OR = 0.878, 95% CI 0.719-1.073), asi kwete yekudzivirira kubva kune ropa (35% vs. 26%, OR = 1.424, 95% CI 1.177-1.723).PermaNet Dual ndiyo imwe sarudzo kune iyi inoshanda zvakanyanya mhando yemambure yekuvandudza kudzora kwemarariya inoparadzirwa nepyrethroid-resistant mosquito.
Mambure ane mishonga yekuuraya zvipembenene (Insecticide-treated bed nets) (ITNs) ndiwo anonyanya kushanda uye anoshandiswa zvakanyanya kudzivirira malaria.Vave vachiratidzwa kakawanda kuti vaderedze chirwere chemalaria uye kufa mukuedza uye zvirongwa zvepurogiramu uye vakaita mupiro mukuru pane chero ipi zvayo ichangobva kupindira kuderedza chirwere chemalaria.Zvisinei, kuvimba kwavo neboka rimwe remishonga inouraya zvipembenene (pyrethroids) kunoita kuti pasave nesimba, zvichikurudzira kupararira kwepyrethroid resistance mumavector emarariya.Pakati pa2010 na2020, kuramba kwepyrethroid kwakaonekwa mune ingangoita imwe vheji mhando mu88% yenyika dzine marariya.Kunyange zvazvo zvidzidzo zvakaratidza kuti mambure ane mishonga yezvipembenene anodzivirira pamarariya pasinei nekurwisa, pane humbowo hwakasimba hwekuti umhutu hunowanikwa mumambure ane pyrethroid hwakavandudza kurarama uye kudya.Tichifunga nezvekukosha kwazvo pakudzivirira nekudzora marariya, chero kumwe kudzikiswa kwekushanda kwemambure ane mishonga yezvipembenene kunogona kukonzera kutangazve kwezvirwere uye kufa.
Mukudavidza kutyisidzira uku, mambure ane maviri-anoshanda ane mishonga yezvipembenene, ayo anobatanidza pyrethroid nemumwe musanganiswa, akagadzirwa kuti adzorere kudzora kwemalariya anodzivirira pyrethroid.Yekutanga mhando nyowani yeITN inosanganisa pyrethroids nePIPERONYL BUTOXIDE (PBO), synergist inowedzera kushanda kwepyrethroids nekuita neutralizing detoxifying enzymes inobatanidza nepyrethroid resistance10.Mudzimba dzekuyedza uye cluster randomized controlled trials (cRCT) ITNs dzine pyrethroids nePBO dzakaratidza hukuru hweentomological mabhenefiti zvichienzaniswa neITNs dzine chete pyrethroids uye epidemiological efficacy.Kubva ipapo vakagamuchira kurudziro yeWHO yekugovera munzvimbo idzo mavekita anoratidza kuramba kune pyrethroids, zvichikonzera kuwedzera kukuru kwekuparadzirwa kwavo munyika dzine dambudziko mumakore achangopfuura18.Nekudaro, iyo pyrethroid-PBO ITN haina miganhu.Zvinonzwisisika, pane kushushikana pamusoro pekusimba kwavo mushure mekushandisa kwenguva refu pamba.Zvidzidzo zvevatyairi muWest Africa zvinoratidzawo kuti pyrethroid-PBO mosquito nets inogona kupa bhenefiti shoma munzvimbo dzine kuwedzera kwekudzivirira kwepyrethroid kunoyananiswa nemaitiro akaomarara uye akawanda.Nokudaro, kuitira kutonga kwevector kunoshanda uye kwakasimba, zvakakosha kushandisa mamwe marudzi emambure ane mishonga yezvipembenene, zvichida ane mamwe mishonga mitsva iyo mavector anonzwa.
Munguva pfupi yapfuura, mambure ane mishonga yezvipembenene ave aripo anobatanidza pyrethroids nefipronil, mushonga weazole unovhiringidza mitochondrial basa.Chlorfenopyr inomiririra nzira itsva yekudzora zvirwere zvezvirwere zvakagadzira nzira dzakaoma dzekudzivirira kune zvipembenene zviripo.Iyo pyrethroid-chlorphenopyr ITN (Interceptor G2), yakagadziridzwa neBASF, yakaratidza marariya inodzivirira pyrethroid mukuedza kuedza muBenin, Burkina Faso, Côte neTanzania.Vector control yave nani uye ikozvino World Health Organisation yakafanirwa.Zviyedzo zvakakura uye zvirongwa zvekugovera zvekuyedza mune dzimwe nyika zvakaratidzawo humbowo hwechirwere chechirwere.Kunyanya, maRCTs muBenin neTanzania akaratidza kuti Interceptor G2 yakaderedza chirwere chemalaria muvana ne 46% uye 44% pamakore maviri, zvichiteerana, zvichienzaniswa neITN ichishandisa pyrethroids chete.Kubva pamigumisiro iyi, sangano reWorld Health Organization munguva pfupi yapfuura rakapa kurudziro yakasimba yekushandiswa kwemambure epamibhedha anobatwa nemishonga inouraya zvipembenene pyrethroid-chlorphenopyr pane mambure emubhedha ane pyrethroids oga munzvimbo dzine mavectors asingarwi nepyrethroids.Mambure akaiswa mishonga yezvipembenene kudzivirira marariya.Izvi zvakonzera kuwedzera kukuru kwekudiwa kwepasirese uye maodha emambure eumhutu ane pyrethroid akaiswa munyika dzine dambudziko.Kuvandudzwa kwemamwe marudzi emhando yepamusoro-soro yepyrethroid uye fipronil mambure emibhedha nevagadziri vakati wandei vane hunyanzvi hwekugadzira huchabatsira kuvandudza musika wemambure ane mishonga yekuuraya zvipembenene, kuwedzera makwikwi, uye kuitisa kuti muwane nyore kuwana mambure emubhedha anotengwa nemishonga.Mambure emubhedha.Isecticidal bed nets for optimal vector control.
Nguva yekutumira: Oct-17-2023