Chirwere chekufema kwenguruve chakagara chiri chirwere chakaoma chinotambudza varidzi vemapurazi enguruve.Iyo etiology yakaoma, zvirwere zvakasiyana-siyana, kupararira kwakakura, uye kudzivirira uye kutonga kwakaoma, izvo zvinounza kurasikirwa kukuru kumapurazi enguruve.Mumakore achangopfuura, nguruve purazi yekufema zvirwere zvinowanzopa zvirwere zvakasanganiswa, saka isu tinoshandiswa kudana iyo yenguruve purazi rekufema syndrome.Zvirwere zvakajairika zvinosanganisira Mycoplasma, Haemophilus parasuis, Actinobacillus pleuropneumoniae, nzeve yebhuruu, circovirus uye flu yenguruve.
Nekudzivirira uye kurapwa kwezvirwere zvekufema, tilmicosin ine mhedzisiro yakanaka
Zvirwere zvekufema zvenguruve zvinonyanya kukamurwa kuva mabhakitiriya, mavhairasi uye mycoplasma.Kune mycoplasma uye porcine infectious pleuropneumonia, ikozvino yakajairika mishonga inorwisa mabhakitiriya yakagadzira kuramba, uye chizvarwa chitsva chemishonga inorwisa mabhakitiriya inowanzogamuchirwa nekiriniki kudzivirira nekurapa zvirwere zvekufema kwenguruve.Semuenzaniso, tilmicosin, doxycycline, tyvalomycin, nezvimwewo, pamwe chete nemishonga inorwisa mavhairasi yechinyakare yekuChina, zvine simba rakakura.Zvidzidzo zvakaratidza kuti tilmicosin ine chikamu chehutachiona hwehutachiona, uye ine simba rakanaka pakutonga kweporcine kufema chirwere chechirwere chinosanganiswa neporcine PRRS.
Tilmicosinine maitiro akadzama uye ine zvakawanda zvakanaka zvekaviri-layer coating.
Sezvatinoziva tese, tilmicosin ndeimwe yemishonga inoshanda kwazvo yekudzora zvirwere zvekufema mumapurazi enguruve.Nekudaro, mhedzisiro yeakasiyana tilmicosin pamusika haina kuenzana.Sei izvi?Tingasiyanisa sei pakati pavo?Zvakadini nemusiyano wacho?Kune tilmicosin, iyo mbishi zvinhu zvinenge zvakafanana, uye hapana misiyano yakawanda.Kuratidzira mhedzisiro yechigadzirwa, inonyanya kuenderana nemaitiro ayo ekugadzira.Mukugadzirwa kwechigadzirwa, kushingairira kuita zvirinani chigadzirwa kwave kuri kukuru.development trend.
Yepamusoro-sorotilmicosininofanira kuva nemaitiro mana: nguruve dzinoda kudya, kudzivirira gastric, kupera kwematumbo uye kunonoka kusunungurwa.
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Siyana nechitarisiko
1. Iyo isina kuvharwa tilmicosin particles yakanyatsonaka uye iri nyore kunyunguduka pakamuri tembiricha, nepo yakavharwa tilmicosin zvimedu zvakakora uye zvakaoma kunyungudika pakamuri tembiricha.
2. Tilmicosin yakanaka (yakadai seChuankexin yakavharwa ne-double-layer microcapsules) ine yunifomu uye yakatenderedzwa zvikamu.Kazhinji, zvimedu zvetilmicosin zvakavharwa zvinosiyana muhukuru uye kufanana.
Siyanisa kubva pakuravira mumuromo (kunaka palatability)
Tilmicosininoravira inovava, uye iyo isina kuvharwa tilmicosin haina kukodzera kupihwa nemuromo.Tilmicosin ine kuravira inovava mumuromo haingogone kuwana isingadikanwi zvinodhaka, asi zvakare inokanganisa zvakanyanya kudyiwa kwenguruve uye inokonzera kukuvara kukuru.Kurasa zvinodhaka.
Siyanisa kubva kugastric solubility uye enteric solubility
1. Kuputira kwetilmicosin kwakakamurwa kuva enteric (asidhi-resistant asi kwete alkali-resistant) kupfeka uye gastric-soluble (kwete acid- uye alkali-resistant) kupfeka.Gastric-soluble (isingamiri kune acid uye alkali) yakavharwa tilmicosin ichanyungudutswa uye inoburitswa negastric acid mudumbu, uye kana mushonga wacho waburitswa, uchaita kuti gastric mucosa ibudise muto wegastric, uye muto wakawandisa wegastric unogona kukonzera nyore. gastric kubuda ropa uye gastric ulcers.Kana mushonga wacho wakanyungudutswa mudumbu uye wakasunungurwa kare, bioavailability yemishonga ichaderedzwawo zvikuru.Kazhinji, kushanda kwemushonga wakanyungudutswa mudumbu kuchaderedzwa neinopfuura 10% kana ichienzaniswa neiyo muura.Izvi zvinonyanya kuwedzera mutengo wemishonga.
2. Enteric coating (anti-acid asi kwete anti-alkali) Kuvhara kunogona kunyungudutswa uye kusunungurwa kuburikidza negastric acid mamiriro ezvinhu asingasviki mumamiriro e-alkaline emukati, kudzivirira maitiro akasiyana-siyana uye maitiro e cardiotoxic anokonzerwa nekutanga kusunungurwa mudumbu.Panguva imwecheteyo, bioavailability yemishonga mumatumbo inovandudzwa.Kukurumidza kusunungurwa muura.
Enteric coating inoshandisa zvakasiyana zvekupfekedza zvinhu uye maitiro, uye kuburitsa kunyatsoita mumatumbo kwakasiyanawo.Kupfeka kwakajairika kunonyungudika zvishoma uye kuburitswa mudumbu mhango uye gastric mhinduro, iyo yakasiyana zvakanyanya nemhedzisiro yekaviri-layer microcapsule coating, uye chiyero chekunyura mudumbu chinokurumidza.
Nguva yekutumira: Mar-17-2022